At the site level, the roles and responsibilities of the Head of Investigation, particularly when it comes to delegated sponsorship missions, should be documented and agreed upon (see Sponsorship Station). Contracts and agreements can be concluded at many levels; internal or external and both legal and non-legal. Examples include the content of contracts and agreements that contracts and agreements should be concluded prior to the commencement of a study and be subject to regular review to ensure that they remain current and relevant. For non-commercial studies carried out in England, the HRA activity statement may be used as an agreement between the sponsor and a participating website and may be sent to the HRA website. Many parties can be involved in conducting and managing a clinical trial and it is important that each party has a clear connection to what is expected of them. . . .